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Pharmaceutical innovation refers to the process of discovering, developing, and bringing new drugs and medical treatments to the market. It encompasses the entire lifecycle of a pharmaceutical product, from initial research and development through clinical trials to regulatory approval and commercialization. Innovation in the pharmaceutical industry involves the application of scientific knowledge, technological advancements, and creative approaches to address unmet medical needs and improve patient outcomes.

Drug discovery is the process by which new medications or therapeutic compounds are identified, designed, and developed for treating diseases. It is a complex and multifaceted undertaking that involves several stages, from the initial identification of a potential drug target to the eventual introduction of a new drug to the market.
Here's an overview of the key steps in the drug discovery process:
  • Target Identification and Validation
  • Preclinical Testing
  • Clinical Trials
  • Regulatory Approval
  • Market Introduction

 

Pharmaceutical innovation refers to the process of discovering, developing, and bringing new drugs and medical treatments to the market. It encompasses the entire lifecycle of a pharmaceutical product, from initial research and development through clinical trials to regulatory approval and commercialization. Innovation in the pharmaceutical industry involves the application of scientific knowledge, technological advancements, and creative approaches to address unmet medical needs and improve patient outcomes.

 

 

Healthcare information technology is the area of information technology systems that involves the design, development, creation, use, and maintenance of information system approaches to improve public health, medical care, lower costs, increase efficiency, reduce errors, and improve patient satisfaction. These include the efficient collecting and analysis of patient data, the development of new therapies and medications, and the application of data analytics, artificial intelligence, cognitive computing, and many other technologies. For the healthcare sector, technology in pharma sciences includes the design, development, implementation, usage, and maintenance of information system approaches to improve patient happiness and public health.

 

Drug discovery is the process by which new medications or therapeutic compounds are identified, designed, and developed for treating diseases. It is a complex and multifaceted undertaking that involves several stages, from the initial identification of a potential drug target to the eventual introduction of a new drug to the market.
Here's an overview of the key steps in the drug discovery process:
  • Target Identification and Validation
  • Preclinical Testing
  • Clinical Trials
  • Regulatory Approval
  • Market Introduction

 

The primary benefit of Novel medication Delivery System is regulated medication delivery to the target site, which results in greater efficacy and fewer side effects. It uses two methods  spatial drug delivery, which includes directing a medication to a specific organ or tissue, and temporal drug administration. Various strategies are used in this to control how quickly the medicine is delivered to the target area. With the use of a novel drug delivery system, the medicine is delivered to the target spot in a regulated way for greater effectiveness and fewer adverse effects. It uses two methods: spatial drug delivery, which includes directing a medication to a specific organ or tissue, and temporal drug administration.

Bioavailability:  The rate and extent to which an active ingredient or active component of a drug product is absorbed and made available at the site of action is known as bioavailability. The area under the blood or plasma concentration-time curve and the highest concentration are typically used to determine the extent and pace of drug absorption, respectively.

Bioequivalence: Two drug products or two drug formulations are said to be bioequivalent or therapeutically equivalent when they have the same therapeutic impact. This indicates that there is no discernible difference in their rates and levels of absorption at the site of action.

Clinical trials and clinical research benefit greatly from clinical pharmacy and pharmacy practises. Pharmacists now take a more active part in devising and changing medication regimens, and their roles in clinical research and patient care have both greatly improved in recent years. The newest developments in clinical research and pharmacy practise are the main topics of this session.

·         Prescribing Drugs

·         Administering Drugs

·         Monitoring Prescriptions

Managing drug use

Personalised medicine is a goal that can be accomplished by doctors with the help of pharmacogenomics and pharmacogenomics. The term "personalised medicine" will eventually refer to drugs that are appropriate not just for the proper patient but also for the particular sickness or disease that is affecting that patient. The current state of clinical practise, medication development, and drug regulation provide significant challenges.

Pharmacoepidemiology is the study of how drugs are used and their impact on large populations of individuals. It provides estimates of both the positive and negative effects of drugs on a population. Epidemiology and clinical pharmacology are stated to be combined in it.

Pharmacology & Toxicology is directly impacted by the research conducted with prescription drugs, vaccines, and OTC drugs being manufactured based on findings from the study of life sciences. Clinical trials are conducted to ensure that products being developed are tested on how well they work on individuals affected by the diseases or conditions they are created to treat.

Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substances, in particular relation to the poisoning of humans.

Pharmaceutical Manufacturing is the process used by businesses that produce pharmaceutical drugs. It faces on going pressure to accelerate innovation and quicken the pace at which they bring profitable products to market. The era of large pharmaceutical firms having a large number of manufacturing facilities is slowly coming to an end, and all businesses, regardless of size, are searching for methods to cut costs in order to compete in an environment that is becoming more challenging and unstable.

At various stages of medication development and commercialization, pharmacoeconomics is examined as part of decision-making processes. Increased decision-making issues and advancements in pharmacoeconomic research methods suggest that pharmacoeconomics will play a larger role in the new millennium. The pharmaceutical industry's businesses will suffer as a result of this.

As many pharmaceutical companies expand their consumer operations and roll out a variety of consumer brands, digital marketing will be the next frontier for them. Historically, tight regulatory limitations have stifled marketing innovation in the pharmaceutical sector. Since consumers exclusively relied on their healthcare practitioners for medical knowledge and guidance in the past, pharmaceutical corporations have had little to no connection with their end-users, or patients.

It is important to remember that people are using the internet more frequently to find answers to questions and problems rather than just to socialise online. In fact, looking for health-related information online ranks third in terms of popularity. Patients no longer take a passive approach to treatment these days.

R&D has always been essential and will likely become much more so in the future for the expansion and success of research-based pharmaceutical enterprises. The pharmaceutical business is currently going through a time of great transformation and uncertainty, which is characterised by increased R&D expenses, depleted pipelines, and financial constraints on performing novel research. All of this is made worse by the global economic crunch, which has resulted in an increase in layoffs and budget cuts for research. However, huge crises can occasionally lead to major possibilities. Through the sharing of risk, cost, and intellectual property through R&D strategic alliances involving all types of innovators, such as pharmaceutical, biotechnology, academic drug-discovery centres, and clinical research organisations, new business models such as open innovation may help resolve the so-called pharmaceutical "productivity paradox."

 

The design, action, delivery, disposition, and use of pharmaceuticals are all addressed by the pharmaceutical sciences, which integrate a wide range of scientific fields. In order to investigate drugs, this field applies the standards of many areas of the fundamental and related sciences, such as measures, chemometrics, arithmetic, material science, and compound building. These areas include science the research of disease transmission, measurements, and chemometrics.

With a focus on creating specialised applications in the biomedical sciences, designing nano materials has now risen to the top of the research priority list. In reality, recent trends in the literature demonstrate that there aren't enough thorough evaluations that focus on the state of knowledge regarding the creation and design of nano materials. The performance of nanoparticles (NPs) is affected by a number of parameters, including size, shape, surface charge, and microstructures. Additionally, it is discovered that these properties depend on how they were synthesised.

Drug development is still a time-consuming, expensive, complex, and ineffective process with a high attrition rate of novel therapeutic discovery, despite advancements in biotechnology and our understanding of biological systems. Drug development is the creative process of creating new drugs based on an understanding of a biological target. Although there have been several advancements in the field of drug discovery that have seen the process' timeframes, complexity, cost, and precision improve, there is still a long way to go. These facts continue to be difficulties for finding new drugs in the modern day.

The field of applied microbiology includes pharmaceutical microbiology. It entails the investigation of microorganisms related to the production of pharmaceuticals, such as reducing the quantity of microorganisms in a processing environment, excluding microorganisms and microbial by products like exotoxin and endotoxin from water and other starting materials, and guaranteeing the sterility of the final pharmaceutical product. The study and creation of anti-infective agents, the use of microbes to assess the potential mutagenic and carcinogenic effects of drugs, and the use of microbes in the production of pharmaceuticals like insulin and human growth hormone are all additional facets of pharmaceutical microbiology.

The fascinating, quickly developing field of medical research known as "pharmaceutical nanotechnology" focuses on using nano scale materials for drug delivery and/or diagnostic purposes. Nanoparticles for chemotherapy-based TB treatment.  The modified release behaviour of the anti-TB drugs loaded nanoparticles after oral administration was the cause of their increased efficacy. Three important drugs rifampin, isoniazid, and pyrazinamide were combined in PLG-nanoparticles.

Pharmaceutical care is a method in which the practitioner commits to taking care of the patient's medication needs and is held liable for doing so. Responsible medication therapy is offered as part of this practise with the goal of improving patient outcomes. The direct, responsible administration of medication-related care with the goal of attaining specific results that enhance a patient's quality of life is known as pharmaceutical care. Oncological formulations, delayed release formulations, topical medications, and innovative drug formulations are all examples of dosage forms.

Artificial intelligence (AI), machine learning (ML), augmented reality (AR), virtual reality (VR), digital apps, the internet of things (IoT) and organs-on-chips are just a few of the innovations that are starting to change the pharmaceutical industry in the same way they have other sectors like media and retail. Creating environments that encourage dialogue or providing therapies for psychological problems, chronic pain, or palliative care are obvious examples. Medical and pharmaceutical personnel can receive excellent training in these settings.